The authors are developing a program to engage university students and schoolchildren in the study and preservation of natural and cultural heritage through museum exhibitions and scientific and educational collections. They are also advancing interactive methods for engaging visitors to university natural science museums. In addition to operating a youth university museum, the project involves creating and developing a prototype of a comprehensive youth museum on the Moscow State University campus, within the university community, with extensive integration of youth social groups — schoolchildren, students, young scientists, youth sections, and science-oriented public organizations. The Youth Museum project, part of the Moscow State University Development Program, aims to formulate a concept for its creation by testing operational mechanisms at university sites. The museum is envisioned as a mobile-networked entity integrated into the system of scientific and educational organizations. It will offer a creative space for youth within the museum setting, develop a network of interactive platforms, and involve both organizers and visitors in a scientific and educational expedition format. The central hub of the youth museum will be located on the Moscow State University campus (Museum of Earth Sciences and the University Gymnasium). Its mobile-network nature will be implemented through the interaction of hubs and clusters based at the Moscow State University, working with regional scientific and educational organizations (university associations and groups). It will also be integrated with the “Flotilla of Floating Universities”, a scientific and educational expedition in which young participants and volunteers collect natural science and cultural-historical materials for the museum’s collections. The mechanisms for building and operating the university youth museum are being tested at specific sites, including interactions between the university museum and school communities through interdisciplinary exhibitions (“Living Matter in the Geospheres” at the Moscow State University), mobile exhibitions organized as part of the “Flotilla of Floating Universities” expedition, development of a regional hub and its coordination with the central hub (Moscow State University — Tambov State Technical University), expansion of interactive platforms (palaeoecological studies at the Tambov hub), and expeditions of school groups led by teachers under the scientific guidance of university museums.